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human umbilical artery endothelial cells  (Cell Applications Inc)


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    Structured Review

    Cell Applications Inc human umbilical artery endothelial cells
    Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed <t>endothelial</t> cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.
    Human Umbilical Artery Endothelial Cells, supplied by Cell Applications Inc, used in various techniques. Bioz Stars score: 94/100, based on 34 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/huaecs/Human+Umbilical+Artery+Endothelial+Cells%3A+HUAEC/pmc12751044-103-0-8
    Average 94 stars, based on 34 article reviews
    human umbilical artery endothelial cells - by Bioz Stars, 2026-10
    94/100 stars

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    1) Product Images from "Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats"

    Article Title: Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats

    Journal: Clinical Science (London, England : 1979)

    doi: 10.1042/CS20242275

    Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed endothelial cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.
    Figure Legend Snippet: Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed endothelial cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.

    Techniques Used: Gene Expression, Expressing, Western Blot

    Related Articles

    In Vitro:

    Article Title: Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats.
    Article Snippet: .. HUAECs (202-05n, Cell Applications, San Diego, CA) and HCAECs (300-05a, Cell Applications) were used for in vitro experiments. ..

    Article Title: Protective role of CXCR7 activation in neonatal hyperoxia-induced systemic vascular remodeling and cardiovascular dysfunction in juvenile rats
    Article Snippet: .. HUAECs (202-05n, Cell Applications, San Diego, CA) and HCAECs (300-05a, Cell Applications) were used for in vitro experiments. ..

    Cell Culture:

    Article Title: Caspase-1 Inhibition Mitigates Neonatal Hyperoxia-Induced Vascular and Cardiopulmonary Inflammation in Neonatal Rats
    Article Snippet: .. The m ost up-to-date-version is available at https://doi.org/10.1042/C S20242275 Human Umbilical Artery Endothelial Cells, HUAECs (Cat# 202-05n, Cell Applications, San267 Diego, CA) were cultured in a human MesoEndo growth medium (Cat# 212-500, Cell268 Applications, San Diego, CA). .. Human Aortic Smooth Muscle Cells (HASMCs) (Cat# 354-05a;269 Cell Applications, San Diego, CA) were cultured in Smooth Muscle Cell Basal Media.

    Article Title: Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats
    Article Snippet: .. Human Umbilical Artery Endothelial Cells, HUAECs (Cat# 202–05n, Cell Applications, San Diego, CA) were cultured in a human MesoEndo growth medium (Cat# 212–500, Cell Applications, San Diego, CA). .. Human aortic smooth muscle cells (HASMCs) (Cat# 354–05a; Cell Applications, San Diego, CA) were cultured in Smooth Muscle Cell Basal Media.



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    Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed endothelial cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.

    Journal: Clinical Science (London, England : 1979)

    Article Title: Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats

    doi: 10.1042/CS20242275

    Figure Lengend Snippet: Treatment with caspase-1 inhibitor decreased gene expression of ( A ) IL-1β, ( B ) GSDMD and protein expression of ( C ) IL-1β, ( D ) GSDMD in hyperoxia-exposed endothelial cells. ( E ) Representative western blots of IL-1β and of GSDMD in the endothelial cells. In addition, caspase-1 inhibitor also reduced gene expression of ( F ) IL-1β ( G ) GSDMD and protein expression of ( H ) IL-1β, ( I ) GSDMD in hyperoxia-exposed smooth muscle cells. ( J ) Representative western blots of IL-1β and of GSDMD in the smooth muscle cells. n = 4–5/group, data are mean ± SD, two-way ANOVA with Tukey’s multiple comparisons test. * P <0.05 ** P <0.01, *** P <0.001; **** P <0.0001. HYP, hyperoxia; PL, placebo; RA, room air; VX-765, caspase-1 Inhibitor.

    Article Snippet: Human Umbilical Artery Endothelial Cells, HUAECs (Cat# 202–05n, Cell Applications, San Diego, CA) were cultured in a human MesoEndo growth medium (Cat# 212–500, Cell Applications, San Diego, CA).

    Techniques: Gene Expression, Expressing, Western Blot